                         SEQUENCE LISTING

<110>  Sun Pharmaceutical Industries Ltd.
 
<120>  NOVEL GLP-1 ANALOGUE

<130>  SUN-069WO

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Native GLP-1 (7-37)

<400>  1

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  2
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  Liraglutide

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Lys is substituted

<400>  2

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  3
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  Semaglutide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa= Aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Lys is substituted

<400>  3

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  4
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=  Ser, Ser(OMe), D-Ser, D-Ser(OMe), Ala or Aib

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa=  Absent or Gln

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa=  Glu

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa=  Glu

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa=  Ile

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa=  Leu, D-Leu, D-Ile or Ile

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa=  Absent

<400>  4

His Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Xaa 
1               5                   10                  15      


Gly Gln Ala Ala Xaa Glu Phe Xaa Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30          


Xaa Xaa 
        


<210>  5
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Lys is substituted

<400>  5

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Leu 
            20                  25                  30          


<210>  6
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa= Ser(OMe)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Lys is substituted

<400>  6

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Leu 
            20                  25                  30          


<210>  7
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Lys is substituted

<400>  7

His Xaa Gln Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 
1               5                   10                  15      


Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30          


Leu 
    


<210>  8
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa= D-Leu

<400>  8

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Xaa 
            20                  25                  30          


<210>  9
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Lys is substituted

<400>  9

His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Leu 
            20                  25                  30          


<210>  10
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Lys is substituted

<400>  10

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Leu 
            20                  25                  30          


<210>  11
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Lys is substituted

<400>  11

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Ile 
            20                  25                  30          


<210>  12
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = D-Ser(OMe)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Lys is substituted

<400>  12

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Leu 
            20                  25                  30          


<210>  13
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = D-Ser

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Lys is substituted

<400>  13

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Leu 
            20                  25                  30          


<210>  14
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = Aib

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Lys is substituted

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa = D-Leu

<400>  14

His Xaa Gln Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 
1               5                   10                  15      


Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30          


Xaa 
    

